Biodegradable Coatings
Biodegradable polymer-based enabling technologies are being employed for many of the next generation drug-eluting devices, combination products, and biologic-based therapies.
With biodegradable polymers, the drug delivery process can be controlled by either the molecular diffusion process and/or the biodegradation of the matrix. Biodegradable systems are capable of delivering much larger therapeutic molecules (e.g., proteins) than durable polymer systems. Additionally, they have the benefit of being reabsorbed/excreted by the body after a period of time.
SurModics offers three distinct families of biodegradable drug delivery coatings. These options cover a wide range of performance and properties in terms of drug delivery rates, biodegradation times, mechanical properties and biodegradation mechanisms.
SynBiosys™ Biodegradable Drug Delivery System is an innovative polymeric system for the controlled release of small and medium-sized compounds. It is a proprietary family of multiblock copolymers constructed from base units of glycolide, lactide, e-caprolactone, and polyethylene glycol. The system can be formulated to control drug release kinetics and coating/device degradation times.
Eureka™ SOLO Biodegradable Drug Delivery Coating is a part of the Eureka naturally biodegradable family of nano-engineered polysaccharides. These polymers are used to form coatings with state-of-the-art performance in terms of drug elution, drug compatibility and biodegradation. The Eureka SOLO coatings can be used for the controlled delivery of peptides, small hydrophobic drugs and water-soluble compounds.
PolyActive™ Biodegradable Polymeric Drug Delivery System is a fully biodegradable matrix that comprises a family of co-polymers offering a range of release rates simply by varying the monomer ratio in the polymer or the size of hydrophilic monomer component. PolyActive coatings can be used to deliver both small molecule drugs and macromolecule compounds such as proteins, peptides, or nucleic acid polymers. PolyActive coatings are applicable for either biostable or biodegradable medical devices.
