Synthetic Biocompatible Coatings
SurModics employs the strategy of passivation with hydrophilic molecules to mask the underlying surface from the blood/tissues. The passivated surface reduces or prevents the adhesion of unwanted cells and proteins onto the underlying substrate or material, thereby preventing surface-induced blood clotting and/or fibrous encapsulation.
Rejoice™ Biocompatible Coatings were developed as synthetic alternatives to our heparin coatings to improve the biocompatibility of device surfaces. The coating bound to the surface serves to shield blood and/or tissues from the underlying medical device material, such that the body only “sees” the coating on the surface and responds accordingly. The chemical and physical properties of the immobilized coating reduce the likelihood of blood components and other cells adhering to the surface and activating cellular processes, such as the formation of thrombus or emboli (blood clots that release and travel downstream) or fibrous encapsulation of a device, such as an implantable glucose sensor.
SurModics’ patented PhotoLink® photoactivated coupling technology is used to create polymer surfaces that have enhanced biocompatibility properties.
